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Association of elevated serum aminotransferase levels with chronic kidney disease measures: Hispanic community health study/study of Latinos

BMC Nephrology Sep 12, 2021

Missikpode C, Kramer H, Cotler SJ, et al. - The results showed that increased serum aminotransferase levels were not independently correlated with measures of chronic kidney disease (CKD) in this sample of diverse U.S. Hispanic Latino adults.

  • Researchers included a total of 13,006 participants aged 18 to 74 years in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) without viral hepatitis, excessive alcohol consumption, or high transferrin saturation levels.

  • In this study, 41 (0.27) years was the mean (SD) age, and 45 % were male.

  • There was an elevation in serum aminotransferase levels in 18.8 % of the population and were correlated with greater odds of high UACR (OR = 1.31; 95 % CI = 1.10, 1.56) after adjusting for demographic characteristics; this relationship became non-significant after adjustment for metabolic syndrome (OR = 1.11, 95 % CI = 0.92, 1.33).

  • The findings revealed that increased serum aminotransferase levels were not correlated with low eGFR (odds ratio (OR) = 0.73; 95 % confidence interval (CI) = 0.45, 1.18) after adjusting for covariates.

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