Ploubidis GB, Batty D, Patalay P, et al. - Using data from the British National Child Development Study, researchers conducted this birth cohort study of 17,415 participants examining if and how early-life mental health trajectories are associated with biomarkers in midlife and premature mortality. Identification of a 4-group longitudinal typology of early-life conduct problems and affective symptoms was done: (1) stable low, (2) teacher-identified adolescent onset, (3) moderate, and (4) stable high. Observations suggest that individuals experiencing affective symptoms and conduct problems in childhood and adolescence exhibit less favorable levels of biomarkers 28 years later and have raised risk of premature mortality. If causal and generalizable to younger cohorts, these findings, may imply the potential of effective interventions on early-life mental health to aid shift the distribution of risk and improve population health.