Heisler AC, Song J, Muhammad LN, et al. - In this study, the relationship between dysregulated central pain processing and treatment response was ascertained in rheumatoid arthritis (RA). Researchers enrolled a total of 182 participants with active RA and were followed for 12 weeks after initiating a disease‐modifying anti‐rheumatic drug. They evaluated the correlation between baseline central dysregulation and treatment response, characterized by the European League Against Rheumatism (EULAR) response criteria, applying multiple logistic regression adjusted for demographics, RA‐related variables, and psychosocial variables. This study's findings demonstrate that low conditioned pain modulation was significantly correlated with lower odds of good EULAR response, implying that inefficient descending inhibitory mechanisms may be a potential treatment target for further study.