O’Connell J, et al. - Through an observational cross-sectional study of older adults with intellectual disabilities (ID), researchers investigated the association between Drug Burden Index (DBI) score and its two sub-scores—anticholinergic and sedative burden)—with two objective measures of physical performance, grip strength and timed up and go, and a measure of dependency, Barthel Index activities of daily living. Neither grip strength nor timed up and go had any marked correlation with DBI, drug burden anticholinergic (DBA), or drug burden sedative (DBS) score, post-adjustment of confounders like age, level of ID, history of falls, comorbidities, and number of non-DBI medications, Down syndrome (grip strength only), and sex (timed up and go and Barthel Index). Also, in the Barthel Index, greater dependency was related to DBS exposure. Thus no significant associations of DBI, DBA, or DBS scores with grip strength or timed up and go were identified. However, this could be a consequence of established constraints in physical function in such a cohort, long-term exposure to these types of medicines, or lifelong inactive lifestyles. Further, the sedative drug burden was linked to greater dependency in Barthel Index activities of daily living and it could be assessed for further studies.