Kanai M, Shiozaki D, Sakimoto S, et al. - Researchers conducted this single-center cross-sectional cohort study to explore the connections between the disorganization of the retinal inner layers (DRIL) and optical coherence tomography angiography characteristics and visual acuity (VA) outcomes in eyes with macular edema secondary to branch retinal vein occlusion (BRVO). Data were analyzed from 43 patients with macular edema secondary to BRVO that received pro re nata anti-vascular endothelial growth factor therapy. Multilinear regression analysis showed that the extent of macular edema and VD in the 3 × 3 mm ² area was significantly associated with the DRIL development. DRIL severity was correlated with VA and related to the peri-macular perfusion status in eyes with BRVO. The severity of DRIL was impaired by macular edema and macular perfusion. Such findings would contribute to a better understanding of the pathogenesis of DRIL in eyes with BRVO.