Ensrud KE, et al. - Via performing a prospective cohort study across four US sites that included 1,528 community-dwelling women aged ≥ 80 years who were identified as potential candidates for initiation of osteoporosis drug treatment, researchers intended assessed the association of disease definition, number of comorbidities, and prognosis with 5-year hip fracture probabilities. Five-year mortality probability was higher among women with osteoporosis vs women without osteoporosis but at high fracture risk. Women with more comorbidities or worse prognosis had the most pronounced difference. Despite accounting for competing mortality risk, a high 5-year probability of hip fracture in women aged 80 years and older with osteoporosis, including those with more comorbidities or poorer prognosis, was observed. On the contrary, among women without osteoporosis but at high fracture risk, competing mortality risk far overburdened the hip fracture probability, especially for women with more comorbidities or worse prognosis.