Shu Y, et al. - Among middle-aged and older adults in America, researchers explored the connection between dietary selenium intake and telomere length. From the National Health and Nutrition Examination Survey in 1999–2000 and 2001–2002, a total of 3,194 United States adults older than 45 years old were extracted. Utilizing the quantitative real-time polymerase chain reaction (qPCR), leukocyte telomere length was measured. Using a 24-hour dietary recall method, dietary selenium intake was evaluated by a trained interviewer. Every 20 μg increase in dietary selenium intake was linked to 0.42% longer telomere length in all candidates after adjusting potential confounders. In subgroup analyses, in females and non-obese participants, dietary intake of selenium was linked to longer telomere length but not in males and obese participants. Among middle-aged and older adults in America, increased dietary selenium intake was related to longer telomere length. Such results need further corroboration from future prospective studies.