Farjah F, Monsell SE, Gould MK, et al. - Researchers undertook this comparative effectiveness research study of 5,057 people with an incidentally identified lung nodule to assess the link between the intensity of lung nodule diagnostic assessments and outcomes, safety, and health costs. Eligible for inclusion were patients aged 35 years or older, who had no high suspicion of infection, without a history of malignant neoplasm, and who did not have any evidence of advanced lung cancer on nodule detection. A total of 1,925 (38%), 1,863 (37%), and 1,269 (25%) participants received guideline-concordant, less intensive, and more intensive diagnostic evaluations, respectively. Evidence of a link between less intensive diagnostic assessments and more advanced stage at lung cancer diagnosis vs guideline-concordant care was inconclusive; greater procedural complications, radiation exposure, and expenses were found in relation to higher intensities of diagnostic evaluations. These data highlight the requirement for more evidence on better ways to assess lung nodules and to prevent unnecessarily intensive diagnostic assessments of lung nodules.