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Association of diabetes with atrial fibrillation phenotype and cardiac and neurological comorbidities: Insights from the Swiss‐AF study

Journal of the American Heart Association Nov 14, 2021

Bano A, Rodondi N, Beer JH, et al. - In patients having atrial fibrillation (AF) with diabetes, AF symptoms were less often perceived but worse quality of life and more cardiac and neurological comorbidities were present compared with those without diabetes. This gives rise to the question of whether diabetics should be systematically screened for silent AF.

  • A total of 2,411 eligible patients with AF (27.4% women; median age, 73.6 years) who took part in the multicenter Swiss‐AF (Swiss Atrial Fibrillation) study were analyzed to determine the link of diabetes with AF phenotype and cardiac and neurological comorbidities in patients with documented AF.

  • Diabetes was not related to nonparoxysmal AF (odds ratio [OR], 1.01).

  • Less frequently AF symptoms were perceived by diabetics (OR, 0.74) but they experienced worse quality of life (β=−4.54) vs those without diabetes.

  • The probability of having cardiac (hypertension [OR, 3.04], myocardial infarction [OR, 1.55], heart failure [OR, 1.99]) and neurological (stroke [OR, 1.39], cognitive impairment [OR, 1.75]) comorbidities was more in patients with diabetes.

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