Kuzman MR, et al. - In patients with first-episode psychosis (FEP) after 18 months of treatment, researchers examined how cannabinoid receptor CNR1 genotypes are related with changes in neurocognitive performance. In addition, they analyzed changes in perceived levels of stress in association with CNR1 genotypes. From two Croatian psychiatric hospitals, they assessed a sample of 159 patients with FEP at baseline and after 18 months. Only rs7766029 genotypes were identified to be significantly correlated with the change in the Weschler 30′ score (false discovery rate, FDR < 15%) in the fully adjusted analysis for age, sex, cannabis use and negative symptoms. Significant correlation of both rs7766029 and rs12720071 genotypes with the change in perceived levels of stress (FDR < 15%) was observed in the analysis adjusted only for the baseline neurocognitive tests’ scores. Only the link with the rs7766029 genotype stayed significant in the fully adjusted analysis. These observations suggest the possible moderating influence of the rs7766029 CNR1 variants on changes in neurocognitive performance and in perceived levels of stress of patients with FEP over time.