Lieb W, et al. - Researchers investigated the association of tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen type III aminoterminal peptide with incident congestive heart failure and chronic kidney disease (CKD). In 922 Framingham participants (mean age, 57 years; 57% women), plasma total TIMP-1 and procollagen type III aminoterminal peptide levels were measured and, using multivariable-adjusted Cox regression models, were related to the risk of incident CKD and congestive heart failure. An association of baseline plasma concentrations of TIMP-1 with new-onset CKD, even after adjusting for standard risk factors and indicators of systemic inflammation and neurohormonal activation was seen in this community-based sample with almost 20 years of follow-up. An association was observed between baseline circulating TIMP-1 concentrations and a higher risk of incident congestive heart failure in age- and sex-adjusted models; but after adjustment for standard risk factors, the link was weakened. The study results displayed no association of blood procollagen type III aminoterminal peptide levels with the risk of incident CKD or congestive heart failure.