Butwicka A, Olén O, Larsson H, et al. - In a population-based cohort study utilizing data from the Swedish national healthcare and population registers of 6,464 children younger than 18 years born from 1973 to 2013, researchers analyzed the risk of psychiatric morbidity in people with childhood-onset inflammatory bowel disease (IBD), controlling for potential confounding shared among siblings. A total of 1,117 people with IBD received a diagnosis of any psychiatric disorder compared with 38,044 of 323,200 people in the general population during a median follow-up time of 9 years, corresponding to an HR of 1.6, equaling one additional case of any psychiatric disorder per 170 person-years. IBD was significantly linked to suicide attempts, mood disorders, anxiety disorders, eating disorders, personality disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Outcomes were comparable for boys and girls. In the first year of follow-up, HRs for any psychiatric disorder were greatest, however, it continued to be statistically important over more than 5 years. For patients with very early-onset IBD and a parental psychiatric history, psychiatric disorders were especially prevalent. Outcomes were widely validated by sibling comparison, with comparable estimates recorded for any psychiatric disorder and suicide attempt. For patients with childhood-onset IBD, long-term psychological support should be considered.