Butwicka A, Olén O, Larsson H, et al. - In a population-based cohort study using data from the Swedish national healthcare and population registers of 6,464 children younger than 18 years born from 1973 to 2013, researchers analyzed the risk of psychiatric morbidity in individuals with childhood-onset inflammatory bowel disease (IBD), controlling for potential confounding shared among siblings. A total of 1,117 individuals with IBD received a diagnosis of any psychiatric disorder vs 38,044 of 323,200 individuals in the general population, corresponding to an HR of 1.6, equaling one additional case of any psychiatric disorder per 170 person-years. Inflammatory bowel disease was significantly related to suicide attempts, mood disorders, anxiety disorders, eating disorders, personality disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Outcomes were comparable for boys and girls. In the first year of follow-up, HRs for any psychiatric disorder were greatest, however, it continued to be statistically important over more than 5 years. For patients with very early-onset IBD and a parental psychiatric history, psychiatric disorders were especially prevalent. Results were widely validated by sibling comparison, with comparable estimates recorded for any psychiatric disorder and suicide attempt. Long-term psychological support be offered for patients with childhood-onset IBD.