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Association of checkpoint inhibitor–induced toxic effects with shared cancer and tissue antigens in non–small cell lung cancer

JAMA Oncology May 07, 2019

Berner F, et al. - Researchers performed this cohort study of 73 patients with non–small cell lung cancer who received anti–PD-1 (programmed cell death 1) therapy, for the underlying pathophysiologic processes of autoimmune skin toxic effects induced by anti–PD-1 therapy. Non–small cell lung cancers and the skin mediated autoimmune skin toxic effects were noted to share nine T-cell antigens. Mediatory role of these T cells in the tumor regression is suggested in patients who responded to therapy. Findings suggest the predictive value of autoimmune toxic effects associated with checkpoint blockade for clinical responses; these may provide opportunities to identify cancer T-cell targets.
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