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Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: Results from the CAPACITY and ARCADIAN studies

JAMA Neurology Mar 05, 2018

Evered L, et al. - An estimation was performed of the 2 biomarkers of neurological injury (neurofilament light and tau) in plasma in a series of timed collections before and after anesthesia and surgery in patients 60 years and older. It was determined that the neurofilament light was a specific marker of axonal injury, which hinted towards neuronal damage in a number of diseases. Tau proteins served as an integral component of axonal integrity, and increased tau pointed towards neuronal damage. Neurofilament light and tau increases over 48 hours after surgery illustrated that general anesthesia and surgery could be related to neuronal damage in the short term.
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