Vergallo A, et al. - In this large-scale cross-sectional observational monocentric study, researchers assessed how cerebrospinal fluid (CSF) α-synuclein (α-syn) correlates with total and phospho-tau₁₈₁ protein concentrations and brain amyloid load in asymptomatic subjects at risk of Alzheimer's disease (AD). A positive association was found between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. As per data, positive relationships between CSF α-syn and both CSF t-tau and p-tau₁₈₁ concentrations were demonstrated. During the preclinical phase of the disease, a correlation of CSF α-syn with AD-related pathophysiological mechanisms was noted.