Albaugh MD, Ottino-Gonzalez J, Sidwell A, et al. - In this cohort study, researchers aimed at determining the extent to which cannabis use is associated with magnetic resonance imaging–measured cerebral cortical thickness development during adolescence. They conducted linear mixed-effects model analysis employing 1,598 magnetic resonance images from 799 participants from the community-based IMAGEN cohort study. Findings revealed correlation of cannabis use with accelerated age-related cortical thinning from 14 to 19 years of age in predominantly prefrontal regions. The spatial pattern of cannabis-related cortical thinning was noted to be significantly linked with a positron emission tomography–assessed map of cannabinoid 1 receptor availability. Per these findings, cannabis use during middle to late adolescence is possibly linked with altered cerebral cortical development, especially in regions rich in cannabinoid 1 receptors.