Frank GKW, et al. - Authors examined the alterations in brain reward learning response to taste in adolescent anorexia nervosa (AN). In addition, they assessed the association of these responses with treatment response, striatal-hypothalamic connectivity, and elevated harm avoidance. They performed a cross-sectional multimodal brain imaging study of 56 female adolescents and young adults with AN and 52 matched controls. Hyperactivation in the caudate head, nucleus accumbens, and insula was noted in the AN group vs controls, during a classical conditioning paradigm that has been associated with dopamine function. The AN group displayed a positive association of orbitofrontal brain response with harm avoidance and striatal-hypothalamic connectivity, but a negative association with change in body mass index during treatment. Results thereby provide further support to the elevated prediction error (PE) signal in AN and infer a link between PE and elevated harm avoidance, brain connectivity, and weight gain in AN. In adolescent AN, prediction error was suggested to have a pivotal role in driving anxiety and ventral striatal-hypothalamus circuit-controlled food avoidance.