Wang F, et al. - The potential effects of body mass index on the risk of mild cognitive impairment (amnestic and non-amnestic) in the elderly were examined. At baseline and follow-up, unhealthy body mass index levels could influence the risk of both types of mild cognitive impairment (amnestic and non-amnestic).

• A total of 240 amnestic mild cognitive impairment patients, 240 non-amnestic mild cognitive impairment patients and 480 normal cognitive function controls were enrolled.
• The authors collected data on admission and retrospective data at baseline (6 years ago) from their medical records.
• They evaluated cognitive function using Mini-Mental State Examination and Montreal Cognitive Assessment.

• At baseline, being underweight, overweight or obese was correlated with an increased risk of amnestic mild cognitive impairment (OR: 2.30, 95%CI: 1.50 ~ 3.52; OR: 1.74, 95%CI: 1.36 ~ 2.20; OR: 1.71, 95%CI: 1.32 ~ 2.22, respectively).
• At baseline, being overweight or obese was also correlated with an increased risk of non-amnestic mild cognitive impairment (OR: 1.51, 95%CI: 1.20 ~ 1.92; OR: 1.52, 95%CI: 1.21 ~ 1.97, respectively).
• An increased or decreased body mass index at follow-up was correlated with an elevated risk of amnestic mild cognitive impairment (OR: 1.80, 95%CI: 1.10 ~ 3.05; OR: 3.96, 95%CI: 2.88 ~ 5.49, respectively) in subjects with normal weights at baseline.
• However, only an increased body mass index was associated with an elevated risk of non-amnestic mild cognitive impairment (OR: 1.71, 95%CI: 1.16 ~ 2.59).