Bandera EV, Qin B, Lin Y, et al. - Central obesity and higher adiposity were correlated with higher all-cause and breast cancer-specific mortality among Black breast cancer survivors in this population-based cohort study. It has been reported that simple measures of body fat distribution and body composition were useful tools for distinguishing Black women with a higher risk of death after a breast cancer diagnosis.

• The mean (SD) age at breast cancer diagnosis was 54.5 (10.8) years among 1,891 women. In this study, 286 deaths were identified during a median follow-up of 5.9 years (range, 0.5-14.8 years); of those, 175 deaths (61.2%) were associated with breast cancer.

• Results showed that a sum of 1,060 women (56.1%) had obesity, and 1,291 women (68.3%) had central obesity.

• Higher adiposity, especially a higher waist-to-hip ratio, was correlated with worse survival.

• In comparison with women in the lowest quartile, women in the highest quartile of waist-to-hip ratio had a 61% increased risk of dying from any cause (hazard ratio [HR], 1.61; 95% CI, 1.12-2.33) and a 68% increased risk of breast cancer death (HR, 1.68; 95% CI, 1.04-2.71).

• It was shown that the risks of all-cause and breast cancer-specific death were similarly high among women in the highest quartile for waist circumference (HR, 1.74 [95% CI, 1.26-2.41] and 1.64 [95% CI, 1.08-2.48], respectively), percent body fat (HR, 1.53 [95% CI, 1.09-2.15] and 1.81 [95% CI, 1.17-2.80]), and fat mass index (HR, 1.57 [95% CI, 1.11-2.22] and 1.74 [95% CI, 1.10-2.75]); nevertheless, the risk was less substantial for body mass index (HR, 1.26 [95% CI, 0.89-1.79] and 1.33 [95% CI, 0.84-2.10]).

• A higher waist-to-hip ratio was correlated with a higher risk of all-cause death among women who had estrogen receptor-negative tumors (HR, 2.24; 95% CI, 1.14-4.41), women who were postmenopausal (HR, 2.15; 95% CI, 1.28-3.61), and women who were 60 years or older at diagnosis (HR per 0.10-U increase, 1.76; 95% CI, 1.37-2.26) in analyses stratified by estrogen receptor status, menopausal status, and age.