Biswas S, Andrianopoulos N, Dinh D, et al. - Since a protective influence of obesity vs normal body mass index (BMI) has been suggested in earlier studies in patients receiving percutaneous coronary intervention (PCI) but if this effect extends to the extremely obese remains unclear, therefore, researchers focused on the link between BMI and long-term clinical consequences post-PCI in this large multicenter registry-based study. They especially assessed the link between extreme obesity and long-term survival post-PCI. Overall 25,413 patients prospectively enrolled in the Melbourne Interventional Group registry, who had PCI between January 1, 2005 and June 30, 2017, were analyzed. According to World Health Organization–defined BMI categories, the stratification of the patients was done. Participants were observed over a median duration of 4.4 years. National Death Index–linked mortality was the primary endpoint. Findings revealed decreased long-term mortality post-PCI in relation to elevated BMI up to 35 kg/m², an obesity paradox is still apparent in contemporary practice. However, this protective influence seemed not to extend to patients with extreme obesity.