Rasmussen LJH, Moffitt TE, Arseneault L, et al. - In this cohort study involving 1,391 candidates (mean [SD] age, 18.4 [0.36] years; 733 [52.7%] female), researchers ascertained if exposure to adverse experiences, stress, and violence was correlated with an increase in soluble urokinase plasminogen activator receptor (suPAR), a new biomarker of chronic inflammation, levels in young people and inquired the assumption that measuring suPAR in addition to C-reactive protein (CRP) or interleukin 6 (IL-6) levels improves the assessment of the inflammatory burden related to early-life stress. This investigation involved individuals from a 1994 to 1995 birth cohort of twins from the nationally representative Environmental Risk Longitudinal Twin Study in the United Kingdom. Findings suggested an association of exposure to adverse experiences, stress, and violence during childhood or adolescence with elevated levels of the suPAR at 18 years of age, even in children without elevated CRP or IL-6 levels. Adding suPAR information to traditional inflammation biomarkers can enhance the measurement of inflammatory burden related to stress and violence exposure.