Pham TM, Kristiansen EB, Frich LH, et al. - This study sought to distinguish malreduction criteria and inflammatory cytokines associated with functional outcomes after ankle surgery. Researchers obtained synovial fluid from the fractured and healthy contralateral ankles of 46 patients during surgery for chemiluminescence analysis of 22 inflammatory cytokines and metabolic proteins. American Orthopedic Foot and Ankle Society scale, the Danish version of Foot Function Index, EQ-5D-5L index score, the Kellgren-Lawrence score, and joint space narrowing were recorded after 3 and 12 months. After ankle surgery, malreduction of tibiofibular (TF) overlap, TF widening, and tibiotalar tilt were the most important criteria for functional outcome. The data showed that elevated inflammatory cytokine levels after fracture did not affect the functional outcome at 12 months.