Vitale S, Agrón E, Clemons TE, et al. - Researchers investigated if the risk of late age-related macular degeneration or loss of visual acuity could be estimated using 2-year progression along the Age-Related Eye Disease Study age-related macular degeneration (AREDS AMD) scale. Among 3,868 participants in the AREDS, statistically significant correlations were observed between at least 2-step and at least 3-step 2-year progression of AMD score (occurring between baseline and the 2-year study visit) and subsequent 5-year development of neovascular AMD, central geographic atrophy, any geographic atrophy, or best-corrected visual acuity loss. Findings support a possible utility of two-year progression of AMD score in determining the risk of late AMD outcomes and loss of visual acuity; this finding establishes the viability of the AREDS AMD scale in describing AMD progression.