Imber DA, et al. - In this retrospective analysis, researchers assessed mortality and probability of extubation in relation to ideal body weight–adjusted tidal volume in pediatric acute respiratory distress syndrome patients on conventional ventilation with a documented height or length in a PICU at a large, tertiary care children’s hospital. According to actual body weight and two different formulations of ideal body weight, they estimated the tidal volume. Findings revealed no consistent link between tidal volume adjusted for ideal body weight and outcomes, although certain subgroups could exhibit an association. On adjusting for oxygenation index in the whole cohort, there was no link between tidal volume, based on both actual body weight and ideal body weight, and increased mortality as well as decreased probability of extubation. In subgroup analyses, overweight children and those with severe pediatric acute respiratory distress syndrome exhibited poor outcomes in relation to higher tidal volume. For titrating lung-protective ventilation, tidal volume likely represents an imprecise parameter.