Pandya C, et al. - Using a cross-sectional design, researchers assessed the independent link between symptom burden and physical function impairment in patients with cancer aged ≥ 65 years. Eligible participants had undergone geriatric assessment (GA). Researchers used a Clinical Symptom Inventory (CSI) scores to determine symptom burden. By assessing impairments of instrumental activities of daily living (IADLs) and using the Medical Outcomes Survey (MOS) and Short Physical Performance Battery (SPPB), they determined functional impairment. Higher prevalence of IADL impairment, physical activity limitation, falls, and SPPB score of ≤ 9 were the findings in patients in the highest quartile of symptom burden vs those in the bottom quartile. Increases by 4.8%, 4.4%, 2.9%, and 2.5% in the odds of having IADL impairment, physical activity limitations, falls, and SPPB scores of ≤ 9 , respectively, were noted in relation to each unit increase in CSI score.