Dey AK, Gaddipati R, Elnabawi YA, et al. - This study was conducted to evaluate the relationship between soluble low-density lipoprotein receptor-1 (sLOX-1) and noncalcified coronary burden (NCB) in psoriasis over time. Between January 1, 2013, and October 1, In a cohort study at the National Institutes of Health, 175 consecutive individuals with psoriasis were referred from outpatient dermatology practices. Researchers recruited a sum of 138 individuals with psoriasis who were followed up at 1 year. Using an enzyme-linked immunosorbent assay, circulating soluble lectinlike oxidized low-density lipoprotein receptor-1 levels were estimated blindly by field scientists running undiluted serum. They conducted coronary computed tomography angiography scans to quantify NCB in all 3 major epicardial coronary arteries by a reader blinded to patient demographics, visit, and treatment status. The study found that soluble lectinlike oxidized low-density lipoprotein receptor-1 levels were raised in individuals with psoriasis and were correlated with severity of skin disease. Furthermore, sLOX-1 correlated with NCB independent of hyperlipidemia status, implying that inflammatory sLOX-1 induction may modulate lipid-rich NCB in psoriasis. At 1-year, improvement of skin disease was correlated with a reduction of sLOX-1, showing the potential role of sLOX-1 in inflammatory atherogenesis in psoriasis.