Drivelegka P, Forsblad-d’Elia H, Angeras O, et al. - A population-based cohort (age range, 50–64 years) was conducted to evaluate the relationship between the serum urate (SU) concentration and subclinical atherosclerosis, as reflected in the coronary artery calcification (CAC) score, common carotid intima-media thickness (CIMT), and carotid plaque score. The research included a total of 1,040 individuals (48.8% males) in the Swedish CArdioPulmonary bioImage Study (SCAPIS) Pilot cohort. There were no differences in age, BMI, education level, smoking, physical activity, hs-CRP, hypertension, and dyslipidemia between males and females, while CAC and diabetes were both twice as common in men than in women. The results showed that higher levels of SU are correlated with the presence of CAC in men but not in women, whereas SU is not correlated with CIMT or carotid plaques in either men or women. The study suggests that the biological impacts of SU differ in men and women or that SU has varying impacts on different vascular beds or during the different stages of the atherosclerotic process.