Nam KH, et al. - In 2,168 participants of the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease, researchers assessed the link between serum high-density lipoprotein cholesterol (HDL-C) levels and the risk of chronic kidney disease (CKD) progression. They evaluated the composite of a 50% decline in estimated glomerular filtration rate from baseline or end-stage renal disease (primary outcome), as well as the onset of end-stage renal disease (secondary outcome). A median follow-up of 3.1 years revealed the occurrence of the primary outcome in 15.5% of the patient population. According to findings, a U-shaped link between serum HDL-C levels and adverse renal outcomes was evident. In patients with nondialysis CKD, a detrimental impact for both low and high serum HDL-C levels was noted.