Li H, Wang Y, Xu Y, et al. - In patients on continuous ambulatory peritoneal dialysis (CAPD), lower serum chloride (Cl) concentrations predict a higher risk of all-cause and cardiovascular disease (CVD) death.

• A retrospective cohort study of 1,656 eligible incident patients undergoing CAPD was conducted to examine the link between their serum Cl levels and clinical results.

• In studies of baseline serum Cl, the adjusted hazard ratios for tertile 1 (<100.0 mmol/L), tertile 2 (100.0-103.0 mmol/L) vs tertile 3 (>103.0 mmol/L) were estimated to be 2.34 and 1.73 for all-cause death, 2.86 and 1.90 for CVD mortality, respectively.

• And there was a linear association between serum Cl and mortality.

• The inverse link between serum Cl and CVD mortality was especially accentuated in the participants who were ≥ 50 years or with a history of diabetes.

• A significantly elevated risk of all-cause and CVD death was noted in relation to lower time-varying serum Cl levels.