Lu Q, Wan Z, Guo J, et al. - Researchers conducted this retrospective cohort study to explore the connection between circulating 25-hydroxyvitamin D [25(OH)D] levels and mortality among adults with prediabetes. The sample consisted of 1,5195 adults with prediabetes (aged ≥ 20 years) from the National Health and Nutrition Examination Survey (NHANES) III and NHANES 2001-2014. Data reported that the median (interquartile range) concentration of serum 25(OH)D was 60.5 nmol/L, and only 23.1% had sufficient vitamin D (≥ 75 nmol/L). Elevated serum 25(OH)D concentrations were significantly linked to lower levels of insulin, HOMA-IR, triglyceride, and C-reactive protein, as well as higher levels of high-density lipoprotein at baseline. Three thousand seven hundred sixty-five deaths (including 1,080 cardiovascular disease (CVD) deaths and 863 cancer deaths) were identified during a median follow-up of 10.7 years. There was a 27% lower risk of all-cause mortality and a 34% lower risk of CVD mortality for per unit increment in ln-transformed 25(OH)D. According to the findings, higher serum 25(OH)D concentrations were linked to lower all-cause and CVD mortality in people with prediabetes.