Wang YH, Wintzell V, Ludvigsson JF, et al. - In this propensity score–matched cohort study, researchers intended to determine if there is an association between proton pump inhibitor (PPI) use and risk of asthma in children. Participants in the study were 80,870 pairs (63.0% girls; mean [SD] age, 12.9 [4.8] years) of children who were and were not new users of PPIs. The authors discovered that the risk of asthma was significantly elevated across all age groups and was highest for infants and toddlers with an HR of 1.83 in the group younger than 6 months and 1.91 in the group 6 months to younger than 2 years. Compared with non-use, initiation of PPI use was associated with an increased risk of asthma in children in this cohort study. Only when specifically stated, should proton pump inhibitors be administered to children, weighing the potential benefit against the potential damage.