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Association between pregnancy and long-term cardiac outcomes in women with congenital heart disease

American Journal of Obstetrics and Gynecology Aug 01, 2021

Son SL, Hosek LL, Stein MC, et al. - Researchers investigated the relationship between pregnancy and subsequent long-term cardiovascular health of females suffering from congenital heart disease (CHD). Study population comprised 711 eligible women receiving care in two adult CHD centers from 2014-2019. Data were collected longitudinally from 15 years of age (or time of entry into the healthcare system) until end of the study, death or exit from the healthcare system. This analysis involved 209 parous and 502 nulliparous women. Parous women were more commonly found to have aortic stenosis, bicuspid aortic valve, dilated ascending aorta/aortic root, aortic regurgitation, and pulmonary insufficiency whereas, nulliparous women more commonly presented with dextro transposition of the great arteries, Turner syndrome, hypoplastic right heart, left superior vena cava, and “other” cardiac diagnoses. Findings demonstrated an increase in subsequent adverse long-term cardiac outcomes in relation to pregnancy in women with CHD.

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