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Association between postmortem kidney biopsy findings and acute kidney injury from patients with SARS-CoV-2 (COVID-19)

Clinical Journal of the American Society of Nephrology Apr 02, 2021

Rivero J, Merino-López M, Olmedo R, et al. - Given the correlation of AKI in coronavirus disease 2019 (COVID-19) with higher morbidity and mortality, researchers herein investigated deceased patients with diagnosis of COVID-19 for determining their kidney histopathologic characteristics and examined how biopsy findings associated with clinical variables, including AKI severity. This multicenter, observational study included a total of 85 patients; median age of patients was 57 (49–66) years, 69% were men, BMI was 29 (26–35) kg/m2, 51% had history of diabetes, 46% had history of hypertension, 98% received anticoagulation, 66% were on steroids, and 35% received at least one potential nephrotoxic medication. Fifty-four percent of patients had a presence of severe AKI. Observations overall suggest a high prevalence of chronic comorbidities on kidney biopsies. Per biopsy findings, 29% had FSGS, 27% had diabetic nephropathy, and 81% had arteriosclerosis. They indicated acute tubular injury grades 2–3 in 49%. They observed an association of nonrecovery from severe AKI with the presence of pigmented casts. Association of inflammatory markers and medications with specific histopathologic findings was observed among patients dying from COVID-19.

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