Sung CE, et al. - Via analyzing the National Health and Nutrition Examination Survey (NHANES) database and adjusting for potential confounding factors—including age and other systemic comorbidities—researchers examined the connection between periodontitis and cognition impairment. Participants included 4,663 adults aged 20 to 59 years who had received full-mouth periodontal examination and undergone cognitive functional testing. According to results, periodontitis was significantly associated with elevated symbol digit substitution test and serial digit learning test scores by generalized linear regression models after adjusting for demographic factors, education, smoking, cardiovascular diseases, and laboratory data. Thus, findings suggested an association of periodontal status with cognitive impairment in this nationally representative sample of US adults.