Gonzalez-Febles J, Rodríguez-Lozano B, Sánchez-Piedra C, et al. - In order to find out the relationship between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients, researchers performed a cross-sectional study including a total of 164 RA individuals. This study reported socio-demographics and RA disease characteristics, including ELISA-detected ACPA (anti-CCP-2). The periodontal parameters evaluated the exposure: plaque index (PI), bleeding on probing (BoP), probing pocket depth, and clinical attachment levels (CAL). They compared presence and levels of ACPAs (outcome) and exposure variables by both parametric and non-parametric tests and correlations were estimated by adjusted odds ratio (OR). The severity of periodontal conditions such as mean CAL, mean PI, and the number of pockets ≥ 5 mm were linearly correlated with both the presence and levels of anti-CCP antibodies in RA individuals.