Song D, Ying GS, Dunaief J, et al. - A post-hoc secondary data analysis of comparison of age-related macular degeneration treatments trials was done in order to assess the correlation of oral iron supplementation with retinal/subretinal hemorrhage in patients with neovascular age-related macular degeneration (n = 1,165). In 71% of 181 iron users and in 61% of 984 individuals without iron use, baseline retinal/subretinal hemorrhage was present in the study eye, and the correlation was dose dependent. In individuals with hypertension, tron use was related to hemorrhage however, it was not, in participants without hypertension. Among hypertensive individuals without anemia, the relationship of iron use with hemorrhage persisted to be important. Thus, the use of oral iron supplements was related to retinal/subretinal hemorrhage in a dose–response manner in individuals of comparison of age-related macular degeneration treatments trials. Moreover, in individuals with wet age-related macular degeneration, unindicated iron supplementation could be harmful.