Xu H, Xia Y, Li X, et al. - In this clinical cohort involving 2,619 candidates, researchers intended to determine if there is a connection between lipid profiles and obstructive sleep apnea (OSA) during rapid eye movement (REM) or non-REM (NREM) sleep. The sample consisted of patients with at least 30 min of REM sleep. They obtained sleep variables and fasting lipid profiles [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo)A-I, apoB, apoE, and lipoprotein(a) (Lp(a))] from each person. Apnea-hypopnea indices (AHIs) in REM and NREM sleep (AHI_REM and AHI_NREM, respectively) have been reported. In order to evaluate the relationships of AHI_REM and AHI_NREM with lipid profiles, linear regression analysis was used. All demographics, clinical variables, and sleep parameters varied between the groups except for apoA-I when stratified by the AHI_REM severity of OSA. AHI_NREM was associated independently with the greatest serum lipid alterations, including TC, LDL-C, and apoB.