Targher G, Mantovani A, Grander C, et al. - Regardless of the presence or absence of type 2 diabetes (T2DM), liver stiffness, or other potential confounding factors, nonalcoholic fatty liver disease (NAFLD) was linked to cardiac sympathetic/parasympathetic imbalance.

• The sample consisted of 173 people with T2DM and 183 age- and sex-matched nondiabetic controls.

• One hundred seventeen people with NAFLD and T2DM, 56 people with T2DM alone, 68 people with NAFLD alone, and 115 people with neither condition were included in the study.

• People with T2DM and NAFLD, as well as those with NAFLD alone, but not those with T2DM alone, had a significantly higher risk of cardiac sympathetic/parasympathetic imbalance than those without T2DM and NAFLD.

• Age, gender, BMI, hypertension, dyslipidemia, insulin resistance, hemoglobin A1c, C-reactive protein, and Fibroscan-measured liver stiffness were all taken into account while creating regression models.