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Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: A cohort study

PLoS Medicine Mar 06, 2020

Fenton A, Chinnadurai R, Gullapudi L, et al. - To evaluate whether the presence of an MG is associated with a higher risk of kidney failure or death in individuals with chronic kidney disease (CKD), researchers examined data from 3 prospective cohorts of patients with CKD (not on dialysis or with a kidney transplant): Renal Impairment in Secondary Care (RIISC, Queen Elizabeth Hospital and Heartlands Hospital, Birmingham, UK, N = 878), Salford Kidney Study (SKS, Salford Royal Hospital, Salford, UK, N = 861), and Renal Risk in Derby (RRID, Derby, UK, N = 1,739). Individuals were eliminated whether they had multiple myeloma or any other B cell lymphoproliferative disorder with end-organ damage. In this CKD cohort, the prevalence of MG was higher than that reported in the general population. Nevertheless, it was noted that the presence of an MG was not independently correlated with a significantly higher risk of kidney failure or, unlike in the general population, the risk of death.
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