Wang Y, Song Q, Cheng Y, et al. - Based on the Chengdu Stroke Registry Database, the authors consecutively recruited acute ischaemic stroke (AIS) individuals within 7 days of stroke onset between January 2016 and September 2018 to determine if there is a connection between Non-HDL-C and haemorrhagic transformation (HT), as well as contrast the predictive values of non-high-density lipoprotein cholesterol (Non-HDL-C) and low-density lipoprotein cholesterol (LDL-C) for HT. In total, 2,043 individuals were involved, among whom 232 were identified as HT. An independent association was found between low Non-HDL-C and an increased risk of HT. Non-HDL-C also has comparable impacts as LDL-C for anticipating HT. Such findings suggest that patients with low Non-HDL-C or LDL-C are vulnerable to HT, and these may be used to minimize the HT risk in practice.