av Kak Kollsker S, Coello K, Stanislaus S, et al. - This study was undertaken to investigate the number of recent and lifetime life events in patients with newly diagnosed bipolar disorder (BD), their unaffected relatives (UR), and healthy controls (HC) as well as the impact of severe lifetime life events on the early course of BD. In this study, the number of recent and lifetime life events in 398 patients with newly diagnosed BD, 109 UR, and 214 HC were compared. This study’s findings demonstrate that the experience of severe lifetime life events appears to affect the early course in BD in terms of longer diagnostic delay, more severe psychopathology including more admissions, and a more than doubled risk for previous suicide attempts.