Banerjee U, et al. - Whether the use of intravenous acetaminophen is associated with a reduction in intraoperative opioid consumption and provides significant analgesia during and after transsphenoidal surgery, was investigated in this retrospective study on 413 patients who underwent transsphenoidal surgery for pituitary adenomas. Two groups of patients were formed on the basis of the intraoperative acetaminophen use. Using a prospensity score matching analysis, researchers balanced for important variables between the two groups of treatment. Regression models were also used and a P < 0.05 was considered statistically significant. Each treatment group comprised 126 patients after matching. Findings revealed the need for significantly less amount (a decrease by 14.9%) of opioids during surgery in patients in the acetaminophen group vs those in the non-acetaminophen group. Between those who received intravenous acetaminophen and those who did not, no significantly different postoperative pain, postoperative nausea and vomiting, and sedation scores were noted.