Bae J, Kim J, Lee S, et al. - Researchers conducted this retrospective observational study with the aim to evaluate the correlation between intraoperative hyperoxia and acute kidney injury (AKI) after cardiac surgery involving cardiopulmonary bypass. They used the area above arterial oxygen partial pressure (PaO ₂) threshold of 300 mmHg (AOT ₃₀₀, mmHg × h) as a metric of intraoperative hyperoxia and identified it to be linked with postoperative AKI among adult patients who underwent cardiac surgery with cardiopulmonary bypass using the logistic regression analysis. A PaO ₂ increase of 100 mmHg above PaO ₂ 300 mmHg for an hour was linked with an elevated risk of AKI by 9.4%. Overall findings suggest significant correlation of intraoperative hyperoxia with the risk of AKI after cardiac surgery involving cardiopulmonary bypass.