Toews I, et al. - In this study involving generally healthy or overweight/obese adults and children, researchers evaluated the relationship between intake of non-sugar sweeteners (NSS) and important health outcomes. They searched several clinical electronic databases for relevant studies that reported on generally healthy adults or children who were or were not overweight or obese. Of the 56 eligible studies identified, 35 were observational reviews. The investigators noted a smaller increase in the body mass index z score in children with NSS intake compared with sugar intake, but no significant differences in body weight or in different doses of NSSs were observed. Overall, there was no compelling evidence to indicate significant health benefits of non-sugar sweetener use on a range of health outcomes. The authors cautioned, however, that potential harms from the use of NSS cannot be ruled out.