Sheehy O, et al. - Researchers determined the type of benzodiazepine that places women in early pregnancy at increased risk of spontaneous abortion (SA) in this nested case-control study involving 442,066 pregnancies included in the Quebec Pregnancy Cohort. Each patient was randomly matched with up to five controls. The investigators defined benzodiazepine exposure as ≥ 1 filled prescriptions between the first day of the last menstrual period and the index date (the calendar date of the SA diagnosis). They found that early pregnancies with incident exposure to short- and long-acting benzodiazepines and all specific benzodiazepine agents during early pregnancy were at an increased risk of SA. Insomnia, anxiety, and mood disorders were found to be prevalent during pregnancy. They recommended that clinicians perform a careful evaluation of the risk-benefit ratio of prescribing benzodiazepines in early pregnancy, as alternative nonpharmacologic treatments exist.