Laroy M, Bouckaert F, Vansteelandt K, et al. - Researchers ascertained if hippocampal volume change (HVC) following electroconvulsive therapy (ECT) anticipates the change in memory performance 6 months after the end of the ECT treatment. High-resolution 3D T1-weighted images from 88 patients with late-life depression were assessed within 1 week before and after ECT for determining hippocampal volume (HV). Before and six months after ECT, memory performance was evaluated. According to results, the whole sample showed less pronounced improvement on the VAT (visual memory) in correlation with larger right absolute HVC. Only patients who switched from right unilateral to bitemporal stimulation after six ECT sessions showed influences on the 8-Word Test (verbal memory), Category Fluency Test (semantic memory), and MMSE. Findings suggested no significant association of absolute HVC in the left hemisphere with cognitive change. Such outcomes suggest less improvement in memory performance up to 6 months post-ECT in correlation with larger absolute change in right HV during ECT.