Greenwood EA, et al. - The relationship between health-related quality of life and depression was investigated in women with polycystic ovary syndrome via performing a secondary analysis of a multicenter, randomized clinical trial (Pregnancy in Polycystic Ovary Syndrome II, NCT00719186) comparing clomiphene citrate vs letrozole in the treatment of infertility. Observations revealed reduced quality of life related to polycystic ovary syndrome symptoms in association with depression. Objective measures including body mass index, hirsutism scores and duration of infertility seemed to provide no explanation regarding disturbances in health-related quality of life in depressed women. Assuming the influence of depression on the experience of polycystic ovary syndrome symptoms, researchers recommend considering it when there is significant discordance between subjective and objective measures in women with polycystic ovary syndrome.