Wijarnpreecha K, et al. - The experts undertook this study to determine the association between coffee consumption and renal cell carcinoma (RCC). They found no significant association between coffee consumption and RCC. Thus, coffee consumption was not likely a risk factor for RCC. However, more likewise studies were required to clarify whether coffee consumption has a potential role in reducing the risk of RCC, particularly in males.

Methods

• This study included data from MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception until December 2016.
• Studies that reported odd ratios or hazard ratios comparing the risk of RCC in individuals who consumed a significant amount of coffee (at least 1 cup of coffee per day) versus those who did not consume coffee were included.
• With a random-effect, generic inverse variance method, pooled risk ratios (RR) and 95% confidence interval (CI) were measured.

Results

• 22 observational studies (sixteen case-control and six cohort studies) were included to evaluate the association between RCC and coffee consumption.
• The pooled RR of RCC in individuals consuming coffee was 0.99 (95% CI, 0.89-1.11).
• Subgroup analyses stratified by sex showed the pooled RRs of RCC of 1.15 (95% CI, 0.85-1.55) in females and 0.87 (95% CI, 0.72-1.04) in males, respectively.