El-Baz FM, et al. - In this prospective study, children with ADHD were assessed for circulating zinc and ferritin levels. Then zinc and iron supplements were offered to the deficient ones, which were then compared regarding their Conner scores and Wecsler IQ test before and after treatment. Researchers divided fifty children diagnosed as having ADHD by DSMV criteria into: group I (zinc only deficient),group II (zinc and ferritin deficient),group III (non-deficient). Zinc (55 mg/day) and/or iron (6 mg/kg/day) were provided to cases with a mineral deficiency for 6 months. Group 1 displayed no significant difference between the Wecsler verbal and non-verbal IQ scores and oppositional and cognitive problems in Conner scores before and after zinc supplements, although there was a significant improvement in attention, hyperactivity, emotional liability, and impulsivity. Group II showed significant improvement in verbal and total IQ but not performance IQ after zinc/iron supplements; in addition, there was a significant improvement in hyperactivity, emotional liability and impulsivity in this group with no significant difference in oppositional, cognitive problems and inattention before and after zinc/iron supplements. These findings support using Zinc supplements as an adjuvant to the main treatment that may result in significant improvement of symptoms of ADHD children. However, relative to zinc alone, combined zinc and iron supplements were superior in alleviating ADHD symptoms as well as IQ improvement.